![]() Critical expiratory flow limitation and the consequent dynamic lung hyperinflation appear to be the proximate deleterious events. The derangements in ventilatory mechanics, muscle function, and gas exchange that characterise severe COPD exacerbations with respiratory failure are now well understood. This underscores the heterogeneous physiological mechanisms of this complex disease, as well as the variation in response to the provoking stimulus. ![]() The clinical presentation of exacerbations of COPD is highly variable and ranges from episodic symptomatic deterioration that is poorly responsive to usual treatment, to devastating life threatening events. The effective management of COPD exacerbations awaits a better understanding of the underlying pathophysiological mechanisms that shape its clinical expression. Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with increased morbidity and mortality.
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In Los Angeles, a beat cop, Matt Parkman is able to hear the thoughts of others, which helps him to track an elusive serial hugger. Hawkins, who has eluded authorities a handful of times. A Las Vegas single mother, Niki Sanders, is doing her best to raise her son Micah, but is haunted by her mirror image, all while dealing with her fugitive husband, D.L. Bennet lives a double life that's twisted deep into the world of these heroes. Across the states in Texas, a cheerleader, Claire Bennet learns that she's indestructible, but is unaware that her father, Mr. In New York, Isaac Mendez, a struggling artist with a bad drug habit, is able to paint the future, while Peter Petrelli, a young dreamer, works to convince his brother, politician Nathan Petrelli, that he can fly. 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